By Steven Enoch
The purpose of this e-book is to supply the clinical historical past to utilizing the formation of chemical different types, or teams, of molecules to permit for read-across i.e. the prediction of toxicity from chemical constitution. It covers the clinical foundation for this method of toxicity prediction together with the how you can crew compounds (structural analogues and / or similarity, mechanism of motion) and the instruments to accomplish this. The techniques to accomplish read-across inside of a chemical type also are defined. The e-book will offer concise sensible advice for these wishing to use those equipment (in danger / risk evaluate) and should be illustrated with case reviews. Chemical Toxicity Prediction is the 1st e-book that addresses the concept that of class formation and read-across for toxicity prediction in particular. This subject has particularly taken off long ago few years because of matters over facing the achieve laws and in addition as a result availability of the OECD (Q)SAR Toolbox. a lot (lengthy and complicated) counsel is out there on classification formation e.g. from the OECD and, to a lesser quantity, the eu chemical compounds corporation yet there's no one unmarried resource of knowledge that covers all recommendations in a concise undemanding layout. there's a genuine want for this data as in silico toxicology has come to the fore lately, essentially a result of european achieve laws, but in addition as a result of many different drivers e.g. relief of animal checking out, Cosmetics law. type formation is obvious because the basically useful method of make rational and obvious predictions for complicated (human) toxicological endpoints. The ebook covers all of the parts required to create a powerful class and practice read-across.
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